National Cancer Institute

Questions and Answers About Estimating Cancer Risk in Ashkenazi Jews Who Carry a Specific Mutation in Gene Previously Associated with Colon Cancer
31 Aug 98 | Previous studies have shown that other mutations in the APC gene are associated with a form of hereditary colon cancer, known as Familial Adenomatous Polyposis (FAP). Patients with FAP develop multiple colon polyps at a young age, have a ...

Small Cancer Risk May Be Associated with Alteration in APC Gene
31 Aug 98 | Researchers at the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI) have found that people with a specific alteration in the APC gene, I1307K, may develop cancer at a slightly higher rate than those with ...

Method To Determine Age Individual Women Should Begin Mammogram Screening
28 Aug 98 | Thus, some women and their physicians may want to make decisions about when to begin regular mammograms based on the woman's individual risk of developing breast cancer. Because the incidence of breast cancer in black women in their 40s rises more...

No Increased Risk for Most Cancers Yet Observed in Daughters of Women Exposed to DES in the 1940s and 1950s
18 Aug 98 | The rate for other cancers over this same period was similar for the DES-exposed women and for women not exposed to DES. In particular, the scientists hope to continue to monitor the women for breast cancers in their later years when breast ...

Interim Reports Published on Two European Breast Cancer Prevention Trials
09 Jul 98 | The failure to detect a difference between these groups is in contrast to the approximately 45 percent reduction in breast cancer incidence in women taking tamoxifen in the Breast Cancer Prevention Trial (BCPT). The BCPT found a highly ...

Modest Risks Found in First Population-Based Study of Outpatient Mastectomies
02 Jun 98 | Among the remaining patients during that period, 18.6 percent stayed overnight or had an outpatient procedure; 29.2 percent stayed two days; 22.5 percent stayed three days; 12.6 percent stayed four days; and 6.3 percent stayed five days. Women ...

New Agreement Helps to Improve Transatlantic Cancer Clinical Research
19 May 98 | A major step toward improving and speeding up transatlantic cancer clinical research has been achieved through an agreement between the U.S. Office for Protection from Research Risks (OPRR) and the European Organization for Research and Treatment ...

Adding Taxol® to Initial Chemotherapy May Be New Option When Breast Cancer Has Spread to Lymph Nodes
18 May 98 | Other trials now under way will provide much needed data on the optimal, adjuvant treatment for node positive breast cancer patients. Another NSABP trial for node-positive breast cancer, using Taxotere® (docetaxel), a drug similar to Taxol®, is ...

Scientists Report New Lead in How Anthrax Kills Cells
30 Apr 98 | For years scientists have known that anthrax bacillus produces a toxin containing a deadly protein called lethal factor. * The study is titled, "Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor."

Cigar Smoking Causes Several Cancers and Lung and Heart Disease
10 Apr 98 | The health effects of cigar smoking are the focus of one of the eight chapters making up NCI's new monograph titled Cigars: Health Effects and Trends. Not only can cigar smoking cause many cancers (oral cancers, including throat cancer, and ...

Breast Cancer Prevention Trial Shows Major Benefit, Some Risk
06 Apr 98 | Among these women at increased risk for breast cancer, women under age 50 appeared to suffer no excess risk of adverse effects from use of tamoxifen. "Women who are at an increased risk of breast cancer now have the option to consider taking ...

American College of Surgeons and National Cancer Institute Announce Funding of Clinical Trials Project
27 Mar 98 | The American College of Surgeons and the National Cancer Institute (NCI) will announce on March 27 that the American College of Surgeons Oncology Group (ACoSOG) has received funding to conduct multicenter cooperative group trials in surgical ...

Study in Finland Suggests Vitamin E Prevents Prostate Cancer
17 Mar 98 | The latest analysis from a large prevention trial conducted by the National Cancer Institute (NCI) and the National Public Health Institute of Finland, shows that long-term use of a moderate-dose vitamin E supplement substantially reduced prostate...

New Report on Declining Cancer Incidence and Death Rates; Report Shows Progress in Controlling Cancer
12 Mar 98 | WASHINGTON, March 12, 1998 -- Cancer incidence and death rates for all cancers combined and for most of the top 10 cancer sites declined between 1990 and 1995, reversing an almost 20-year trend of increasing cancer cases and deaths in the United ...

Synthetic Peptide Vaccine for Melanoma Holds Promise
02 Mar 98 | Early clinical trials of a synthetic vaccine are showing promise in obtaining an immune response from patients with melanoma, an often-deadly form of skin cancer, according to researchers at the National Cancer Institute (NCI). This peptide was ...

Scientists Discover A Third Gene Alteration That Slows Progression to AIDS
15 Jan 98 | This makes the SDF-1 alteration far less common than the two previously reported protective mutations in the CCR2 and CCR5 genes, which protect people carrying only one mutated copy. initially noticed the slight alteration, called a polymorphism, ...

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