St. Jude Children's Research Hospital (ALSAC)

Genetic Link Discovered Between Two Inherited Rare Diseases That Each Cause Cancer In Children
17 May 02 | Interactions between the genes mutated in two different rare inherited disorders, Fanconi Anemia and Ataxia-Telangiectasia, provide new insights into tumor development and responses of tumors to therapy. ALSAC covers all costs not covered by ...

Rabbit Liver Protein Provides Clues to Improving Cancer Therapy
02 May 02 | (Memphis, Tennessee, May 2, 2002) A rabbit liver protein can effectively activate the promising anti-cancer drug CPT-11, according to scientists at St. Jude Children's Research Hospital. Rabbit proteins and human proteins are similar, so the ...

New Diagnostic Tool Means Better Treatment for Pediatric Leukemia
27 Mar 02 | Scientists from St. Jude Children's Research Hospital suggest that a new genetic screening technique may lead to dramatic improvement in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). ALSAC covers all costs not covered by ...

Long-elusive mutant mouse gene found: a link between nerve degeneration, regeneration
08 Mar 02 | (Memphis, Tennessee, March 8, 2002) A defective gene responsible for the death of nerve cells in the adult brain of mice has been identified, according to a study led by scientists at St. Jude Children's Research Hospital. This unexpected link ...

Acute myeloid leukemia 'model' may be important research tool for many cancer treatments
28 Feb 02 | (Memphis, Tennessee, February 28, 2002) A method that enables scientists to study the development of an acute myeloid leukemia (AML) in mice should open new research paths for scientists studying cancer in humans. The findings were published in ...

Seriously Ill Kids Put Up Defenses to Hide Depression
29 Jan 02 | "The children are not just engaging in denial or impression management but genuinely think of themselves as well adjusted, self controlled and content," said Sean Phipps, Ph.D., of St. Jude Children's Research Hospital. ALSAC covers all costs not...

Effect of radiation on normal brain identified in a landmark study of children with brain tumors
08 Jan 02 | The study, published in December's Annals of Neurology, is by scientists at St. Jude Children's Research Hospital in Memphis, led by St. Jude's Dr. Grant Steen. The brain consists of roughly equal parts of white matter and gray matter, with gray ...

New hope for infants with sickle cell disease
17 Dec 01 | Sickle cell disease is an inherited disorder of red blood cells that causes the cells to become sickle-shaped and hard, instead of round and soft. Hydroxyurea works by causing the body to produce fetal hemoglobin, which reduces the severity of ...

Cell-enlargement discovery puts new twist on brain tumor research
13 Dec 01 | This research will help scientists understand the underlying mechanisms of how this tumor-suppressor gene may lead to brain tumor formation. The St. Jude scientists, led by Suzanne Baker, Ph.D., created a model system of the tumor suppressor's ...

Better treatment has doubled survival rate of childhood non-Hodgkin lymphoma
26 Oct 01 | (Memphis, Tennessee, October 26, 2001) Better medical therapy has helped double the survival rate of survivors of childhood non-Hodgkin lymphoma (NHL) without additional risk they will develop a second cancer, a recent study shows. ALSAC covers ...

Understanding the nature of infections
20 Aug 01 | (Memphis, TN, August 20, 2001) A scientist from St. Jude Children's Research Hospital co-authored an article appearing in the September-October issue of American Scientist magazine. In "Pathogens, Host-Cell Invasion and Disease," cell ...

Genetic discovery will aid diagnosis of rare childhood cancer
10 Aug 01 | Stephan Morris, M.D., and Zhigui Ma, M.D., Ph.D., of Memphis' St. Jude Children's Research Hospital and Johann Hitzler, M.D., of Toronto's Hospital for Sick Children led the study. The genetic abnormality is likely a factor in the onset of acute ...

New Hope for Children with Sickle Cell Disease
02 Aug 01 | Children with sickle cell disease are getting new hope from an old therapy. Now researchers have discovered that treating sickle cell patients with hydroxyurea is also effective in preventing the excruciating pain crises associated with sickle ...

Study links breast cancer gene to cell-cycle control
15 May 01 | (Memphis, Tennessee, May 15, 2001) Scientists studying links between genetic mutations and breast cancer have confirmed a protein's role in halting replication of abnormal DNA at cell-cycle checkpoints. Research at St. Jude Children's Research ...

New Treatment Likely to Increase Survival Rates in Patients with Medulloblastoma – a Rare Pediatric Brain Tumor
11 May 01 | (Memphis, Tennessee, May 11, 2001) An ongoing study at St. Jude Children's Research Hospital indicates that a new treatment protocol could increase survival rates for some pediatric brain cancers to 80 percent for high-risk and 90 percent for ...

Genes deficiency tied to male mice infertility
01 May 01 | The research, published in Molecular and Cellular Biology by scientists at St. Jude Children's Research Hospital, shows that male mice lacking the Ink4c and Ink4d genes will generate low sperm counts with reduced motility and decreased viability. ...

Cancer Survivors at Greater Risk for Osteoporosis
27 Apr 01 | (Memphis, Tennessee, April 27, 2001) Survivors of childhood acute lymphoblastic leukemia (ALL) are at a greater risk for developing osteoporosis, or reduced bone density, according research from St. Jude Children's Research Hospitalƒ . The team, ...

Log On to GoCollect.com® to Help Raise Money for St. Jude
27 Apr 01 | GoCollect's promotion is in addition to the 5th annual Enesco Cherished Teddies/St. Jude Pin-Up Promotion. Enesco's Cherished Teddies collection and Radio Flyer® also partnered during the promotion to create a special figurine to benefit the kids...

Promising Young Scientist Receives National Award
16 Apr 01 | (Memphis, Tennessee, April 16, 2001) St. Jude Children's Research Hospitalƒ physician and researcher Cynthia Wetmore, M.D., Ph.D., will receive the second annual Peter A. Steck Memorial Award Friday, April 20, at Houston's M. D. Anderson Cancer ...

Scientists Identify a Cause of Drug Metabolism Variations in Humans
29 Mar 01 | The St. Jude team, led by Erin Schuetz, Ph.D., found that, compared to people who express CYP3A5 protein, those persons who do not express, or produce, the CYP3A5 protein may experience altered drug response or toxicity when given drugs ...

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