Researchers Pinpoint Source of Chronic Pain Resulting from Spinal Cord Injury
Yale School of Medicine
The burning, vise-like pain experienced by most people with spinal cord injuries results from overly sensitized nerve cells; this activity can be blocked by administering specially designed molecules, according to Yale researchers.
These results for the first time implicate sodium channels-molecular batteries necessary for conduction of nerve signals-in severe pain following spinal cord injury. The findings also suggest a way to treat this pain by blocking the production of the specific sodium channels, the authors stated in the Journal of Neuroscience October issue.
Spinal cord injury can result in hypersensitivity of pain-signaling nerve cells within the spinal cord. In his study with rats, Bryan Hains, a postdoctoral fellow in neurology and the Veterans Administration Rehabilitation Research and Development Center in West Haven, found a particular type of sodium channel, Nav 1.3, to be present in abnormally high levels within the pain-signaling nerve cells following spinal cord injury. These channels cause the nerve cells to become hypersensitive, allowing them to fire signals at higher-than-normal rates. Normal stimuli then become extremely painful.
Next, Hains and Stephen Waxman, professor and chair of neurology and senior author of the study, injected the rats with specially designed molecules, "antisense oligonucleotides," targeting the problem sodium channel. The injection resulted in decreased production of the Nav 1.3 sodium channels, less hypersensitivity of the pain-signaling nerve cells within the spinal cord, and reduced pain-related behaviors. The pain returned when the treatment was stopped.
"These results demonstrate for the first time that an easily targeted molecule can have dramatic effect on pain after spinal cord injury, which is very exciting," Hains said. However, despite their potential, the results must be replicated and tested in higher-order animals before testing in humans, he said.
The research was supported by the Medical Research Service and Rehabilitation Research and Development Service, Department of Veterans Affairs; the Eastern Paralyzed Veterans Association; the Paralyzed Veterans of America; The Christopher Reeve Paralysis Foundation and the National Institutes of Health-National Institute of Neurological Disorders and Stroke.
For more information, or to contact Yale School of Medicine, see their website at: info.med.yale.edu/ysm/
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